Multi-functional cytotoxic T cell expansion correlates with overall survival after administration of autologous dendritic cell immunotherapy in renal cell cancer patients
نویسندگان
چکیده
Background AGS-003 is an autologous dendritic cell immunotherapy consisting of matured DC co-electroporated with amplified autologous tumor RNA and synthetic CD40L RNA. A Phase 2 trial evaluated AGS-003-induced T cell immunity in RCC patients in combination with sunitinib. A comprehensive immune analysis using an unbiased bioinformatics approach to analyze multi-color flow cytometry data on longitudinal blood draws identified statistically significant correlates between T cell responses and overall survival.
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